Disaster Medical Science Division
Disaster Public Health Lab
Assistant Professor
Ph.D. (Medicine)

Research Subject(s)
Long-term effects of fetal and childhood exposure
Key Words
Disaster Public Health / Child health / Immunological disorder
Research Activities

Using data from the world's first large-scale Three-Generation cohort study, I aim to develop data cohort participants' follow-up and drug and supplement intake, and ultimately determine how fetal and childhood exposures affect later growth and development.

To develop new anti-tumor immunotherapies, I am investigating the involvement of previously unknown molecules in the correlation between the carcinogenic suppressive function of the innate immune system and acquired immunity.

Selected Works

Fatty acid-binding protein 3 controls contact hypersensitivity through regulating skin dermal Vγ4+ γ/δ T cell in a murine model. Kobayashi S, Phung HT, Kagawa Y, Miyazaki H, Takahashi Y, Asao A, Maruyama T, Yoshimura A, Ishii N, Owada Y. Allergy. 2021 Jun;76(6):1776-1788. doi: 10.1111/all.14630. 

The Curcumin Analog GO-Y030 Controls the Generation and Stability of Regulatory T Cells. MaruYama T, Kobayashi S, Nakatsukasa H, Moritoki Y, Taguchi D, Sunagawa Y, Morimoto T, Asao A, Jin W, Owada Y, Ishii N, Iwabuchi Y, Yoshimura A, Chen W, Shibata H. Front Immunol. 2021 Jun 23;12:687669. doi: 10.3389/fimmu.2021.687669.

Costello syndrome model mice with a HrasG12S/+ mutation are susceptible to develop house dust mite-induced atopic dermatitis. Katata Y, Inoue SI, Asao A, Kobayashi S, Terui H, Inoue-Shibui A, Abe T, Niihori T, Aiba S, Ishii N, Kure S, Aoki Y. Cell Death Dis. 2020 Aug 13;11(8):617. doi: 10.1038/s41419-020-02845-8.

GITR controls intestinal inflammation by suppressing IL-15-dependent NK cell activity. Sakurai T, Okuyama Y, Kobayashi S, Phung HT, Asao A, Kawabe T, Ndhlovu LC, Riccardi C, Kudo H, Wada M, Nio M, So T, Ishii N. FASEB J. 2020 Nov;34(11):14820-14831. doi: 10.1096/fj.202001675R. 

Germ-Free Conditions Modulate Host Purine Metabolism, Exacerbating Adenine-Induced Kidney Damage. Mishima E, Ichijo M, Kawabe T, Kikuchi K, Akiyama Y, Toyohara T, Suzuki T, Suzuki C, Asao A, Ishii N, Fukuda S, Abe T. Toxins (Basel). 2020 Aug 26;12(9):547. doi: 10.3390/toxins12090547.