People are greatly stressed by disasters. Stress hormones are secreted in response to stress, promoting an increase in heart rate, body temperature and blood pressure, and enhancing the function of protecting the body. Cortisol, a typical stress hormone, is secreted by the adrenal cortex. Cortisol in the bloodstream is carried to various organs and naturally reaches the uterus. We will investigate the expression of cortisol receptors and cortisol-related enzymes in the endometrium to elucidate stress and uterine diseases.
The secretion of female hormones is regulated by various mechanisms. The amount of estrogen, which is a typical female hormone, changes depending on the life stage of a woman. It is considered that subtly regulated estrogen secretion described above is disrupted by excessive stress. We believe that cortisol signals disrupt the regulation of estrogen pathway, and we are conducting research on cortisol-estrogen signal crosstalk in endometrial cancer, uterine fibroids, and endometriosis. We would like to clarify the relationship between stress and gynecological diseases.
Miki Y, Tase T, Tokunaga H, Yaegashi N, Ito K. Cervical cancer screening rates before and after the Great East Japan Earthquake in the Miyagi Prefecture, Japan. PLoS One. 2020 Mar 11;15(3):e0229924.
Miki Y, Sugawara Y, Shibahara Y, Tsuji I, Sasano H, Ito K. (2019). Multiple primary cancers associated with endometrial and ovarian cancers: An analysis based upon the Japan Autopsy Annual Database from 2002 to 2010. The journal of obstetrics and gynaecology research, 45(5), 1012-1018. doi: 10.1111/jog.13934
Miki Y, Iwabuchi E, Ono K, Sasano H, Ito K. (2019). Exploring Protein⁻Protein Interaction in the Study of Hormone-Dependent Cancers. International journal of molecular sciences, 19(10). pii: E3173. doi: 10.3390/ijms19103173