Organization

Disaster Medical Science Division
Infectious Diseases Lab
Professor
M.D., Ph.D.
 (Concurrent)

Concurrent: Graduate School of Medicine
Research Subject(s)
Infectious diseases, such as Flu and COVID-19, are now a huge threat in the world, and their response is a serious issue. In this field, the theme is not only epidemiology and diagnosis of controlled microorganisms, but also the development of therapeutic agents for infectious diseases such as antiviral drugs. Moreover, we try to clarify the mechanism of drug resistance and improve diagnostic methods.
Key Words
Outbreak / Biosafety / Drug Resistance / Drug Discovery / Antiviral Drug
Website
Research Activities

It is difficult to predict the occurrence of a disaster. Therefore, research on infectious diseases during a disaster has focused on post-mortem epidemiological surveys and vaccine research based on the outbreak-prediction. We found that anti-viral therapy itself has effectively prevented spread of HIV infection worldwide, led us to perform a novel research on anti-virals. Two basic researches are ongoing.

Development of anti-HIV agent: An anti-HIV drug jointly developed with Japan Tobacco Inc. was approved in Japan in March 2013, and in 2016. Another anti-HIV therapeutic drug that are effective in both treatment and prevention (during clinical trials), is in the clinical trial.
Viral carcinogenesis: We also develop a therapeutic drug for chronic active EBV infection with Tokyo Medical and Dental University and the National Center for Child Health and Development.

In addition to basic research, we are also involved in disaster infection control activities and infection control at medical institutions. We supervised the renewal of infectious diseases on the disaster prevention and mitigation information site of Tokyo Marine & Nichido. It focuses on infectious diseases that occur frequently (http://www.tokiomarine-nichido.co.jp/world/egao/). In addition, I am engaged in infection control activities as a member of the Japanese Infectious Diseases Societies, and local governments such as Miyagi Prefecture and Sendai City, and JICA.

Selected Works

Tsukada, et al. Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones. Nature Communications 11, Article number: 1830, 2020 

Salie Z. L. et al. Structuralbasis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA). Proc Natl Acad Sci U.S.A., 113:9274-9, 2016.

Asai T.et al. Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides. Nature Chemistry7: 737-43, 2015.

Hatanaka Y. et al. Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons. Proc Natl Acad Sci U.S.A., 112:14641-6, 2015.

Selected Memberships
  • Japanese Association for Disaster Medicine
  • Japanese Society for Infection Prevention and Control
  • The Japanese Society for Virology
  • The Japanese Association for Infectious Diseases