Lecturer (Specially Appointed)
Ph.D.
SUZUKI Masatoshi
Concurrent: Graduate School of Medicine
Organization
Research Division
- Risk Evaluation and Disaster Mitigation Research Division
- Disaster Humanities and Social Science Division
- Disaster Medical Science Division
- Practical Research and Collaboration Division
- Endowed Research Division
- Joint Research Division
- Co-creation Center for Disaster Resilience
- Global Centre for Disaster Statistics
- Kesennuma Satellite Office
- Public Relations Office
- Administration Office
- Research Subject(s)
- Our group aims to elucidate the health impact by the accident of Fukushima Dai-ichi nuclear power plant. We have collected the biological samples of non-human primate and environmental samples in the ex-evacuation zone and have establishesed the sample archive. We also performes multidisciplinary research by the collaboration using our archive samples and revealed individual radiation dose as well as biological effects at molecular and cellular level. Our activity contributes to the accumulation of the scientific knowledge to be applied to radiation safety management of the people who suffered radiation disaster and decommissioning workers.
- Key Words
- Radiation effects / radiation disaster / radioactive microparticle / low dose/low dose rate radiation exposure
- Website
- Research Activities
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The biological effects of long-term radiation exposure especially in the low dose and low dose-rate areas have become a social concern after the accident of Fukushima Dai-ichi nuclear power plant. We focuses on the health impact of a non-human primate Japanese macaques which exposed to radiation in the ex-evacuation zone. We established the method of dose evaluation to optimize to Japanese macaque and evaluated radiation dose of individuals1, 2). We also demonstrates slight increase of oxidative stress in plasma and slight decrease of hematopoietic function in bone marrow which depends on internal dose-rate3, 4).
In addition to the soluble form, it has been confirmed that radiocesium was released into the environment as the form of insoluble microparticle by the accident of Fukushima Dai-ichi nuclear power plant. It is expected that inhalation of small-sized particles will deeply reach inside the body and cause long-term exposure. Cs-bearing microparticle (CsMP) which isolated from the soil in the ex-evacuation zone were co-cultured with normal human cells and we are looking for the effects by local exposure.
Our group has established normal human cells that have acquired resistance to lethal fractionated radiation exposure. We are currently elucidating the molecular mechanism of this resistant phenotype. We have also confirmed that the acquired resistant cells also demonstrated the resistance to the lethal tritium treatment. Elucidation of the molecular mechanism will provide basic knowledge for the development of radioprotective agents to apply to emergency exposure.
- Selected Works
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Suzuki M, Suzuki H, Ishiguro H, Saito Y, Watanabe S, Kozutsumi T, Sochi Y, Nishi K, Urushihara Y, Kino Y, Numabe T, Sekine T, Chida K, Fukumoto M. (2019) Correlation of Radiocesium Activity between Muscle and Peripheral Blood of Live Cattle Depending on Presence or Absence of Radiocontamination in Feed. Radiation Research, in press, doi: 10.1667/RR15418.1.
Urushihara Y, Suzuki T, Shimizu Y, Ohtaki M, Kuwahara Y, Suzuki M, Uno T, Fujita S, Saito A, Yamashiro H, Kino Y, Sekine T, Shinoda H, Fukumoto M. (2018) Haematological analysis of Japanese macaques (Macaca fuscata) in the area affected by the Fukushima Daiichi Nuclear Power Plant accident. Scientific Reports, 13;8(1):16748. doi: 10.1038/s41598-018-35104-0.
Nakamura AJ, Suzuki M, Redon CE, Kuwahara Y, Yamashiro H, Abe Y, Takahashi S, Fukuda T, Isogai E, Bonner WM, Fukumoto M. (2017) The Causal Relationship between DNA Damage Induction in Bovine Lymphocytes and the Fukushima Nuclear Power Plant Accident. Radiation Research, 187(5):630-636. doi: 10.1667/RR14630.1.
Suzuki M, Suzuki K, Kodama S, Yamashita S, Watanabe M. (2012) Persistent amplification of DNA damage signal involved in replicative senescence of normal human diploid fibroblasts. Oxidative Medicine and Cellular Longevity, 2012:310534. doi: 10.1155/2012/310534.
Suzuki M, Yamauchi M, Oka Y, Suzuki K, Yamashita S. (2012) Live-cell imaging visualizes frequent mitotic skipping during senescence-like growth arrest in mammary carcinoma cells exposed to ionizing radiation. International Journal of Radiation Oncology, Biology and Physics. 83(2):e241-50. doi: 10.1016/j.ijrobp.2011.12.003.
- Selected Memberships
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- The Japanese Radiation Research Society
- Japanese Cancer Association
- Selected Awards
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- Best prsentation award for Radiation workshop of JRRS (2015)